Hydroxylamine Inhibition of Xanthine Oxidase
نویسندگان
چکیده
In the course of investigations regarding the effects of various chemical agents on neoplast,ic purine metabolism, it was observed that hydroxylamine prevents the accumulation of uric acid or allantoin that normally occurs upon incubation of crude tissue homogenates. Subsequent studies, reported in this paper, demonstrate that hydroxylamine is a competitive inhibitor of xanthine oxidase activity, the dehydrogenase portion of the enzyme apparently being the site of inhibition.
منابع مشابه
Evidence indicating a chemical reaction between hydroxylamine and riboflavin.
The observation that hydroxylamine inhibits xanthine oxidase activity through interference with the dehydrogenase portion of the enzyme (1) led us to determine whether hydroxylamine forms a chemical complex with riboflavin or its biological derivatives, riboflavin-5phosphate (FMN) and flavin adenine dinucleotide (FAD). These studies were stimulated by those of Kaplan and his group, who explaine...
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