Hydroxylamine Inhibition of Xanthine Oxidase

نویسندگان

  • ELEANOR BORRIES
  • Damon Runyon
چکیده

In the course of investigations regarding the effects of various chemical agents on neoplast,ic purine metabolism, it was observed that hydroxylamine prevents the accumulation of uric acid or allantoin that normally occurs upon incubation of crude tissue homogenates. Subsequent studies, reported in this paper, demonstrate that hydroxylamine is a competitive inhibitor of xanthine oxidase activity, the dehydrogenase portion of the enzyme apparently being the site of inhibition.

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تاریخ انتشار 2003